|
| Status |
Public on May 31, 2017 |
| Title |
FOXP3-mediated inhibition of a global gene regulator is required for maintaining Treg cell commitment |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Regulatory T (Treg) cells are characterized by the forkhead transcription factor FOXP3. Mutations in FOXP3 cause autoimmunity in mice and humans. Here, Treg cells as well as conventional T cells were isolated from B-CLL patients and analyzed by global gene expression analysis in order to identify biological differences in Treg cells of CLL patients.
|
| |
|
| Overall design |
Freshly isolated peripheral CD4+ T cells of CLL patients, separated into CD25 negative and positive subpopulations.
|
| |
|
| Contributor(s) |
Classen S, Schultze J |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jul 08, 2009 |
| Last update date |
May 31, 2017 |
| Contact name |
Joachim Schultze |
| E-mail(s) |
j.schultze@uni-bonn.de
|
| Organization name |
LIMES (Life and Medical Sciences Center Genomics and Immunoregulation)
|
| Department |
Genomics and Immunoregulation
|
| Street address |
Carl-Troll-Strasse 31
|
| City |
Bonn |
| State/province |
NRW |
| ZIP/Postal code |
53115 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL2507 |
Sentrix Human-6 Expression BeadChip |
|
| Samples (12)
|
|
| Relations |
| BioProject |
PRJNA117309 |
Less...
More...