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| Status |
Public on Apr 01, 2021 |
| Title |
T3-Dependent Transcriptional Programming by TR-beta Requires SWI/SNF Chromatin Remodelers (CUT&RUN) |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We used an integrated genomics approach to profile and characterize the cistrome of TR-beta, map changes in chromatin accessibility, and capture the transcriptomic changes in response to T3 in a normal thyroid cell line. Our data demonstrates that T3 promotes significant shifts in TR-beta genomic occupancy, which are associated with differential chromatin accessibility, and differential recruitment of SWI/SNF chromatin remodelers.
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| |
|
| Overall design |
Epigenetic and transcriptomic anlaysis a of thyroid hormone receptor beta binding and regulation of chormatin accessibility in normal thyroid cells in the presence and absence of thyroid hormone.
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| |
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| Contributor(s) |
Gillis N, Frietze S, Carr F |
| Citation(s) |
35037038 |
| |
| Submission date |
Mar 10, 2021 |
| Last update date |
Mar 04, 2022 |
| Contact name |
Noelle E Gillis |
| E-mail(s) |
gilli431@umn.edu
|
| Organization name |
University of Minnesota
|
| Street address |
2231 6th ST SE, CCRB
|
| City |
Minneapolis |
| State/province |
Minnesota |
| ZIP/Postal code |
55455 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL18460 |
Illumina HiSeq 1500 (Homo sapiens) |
|
| Samples (17)
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| This SubSeries is part of SuperSeries: |
| GSE168954 |
T3-Dependent Transcriptional Programming by TR-beta Requires SWI/SNF Chromatin Remodelers |
|
| Relations |
| BioProject |
PRJNA713340 |
| SRA |
SRP310146 |
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