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| Status |
Public on Oct 19, 2022 |
| Title |
Profiling subcellular localization of nuclear-encoded mitochondrial gene products in zebrafish |
| Organism |
Danio rerio |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Analysis of subcellular location of mitochondrial gene products using two distinct cell fractions: membrane-bound (MB) and high speed (HS) obtained via biochemical fractionation from wild type individuals and mia40a zebrafish mutants, respectively.
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| Overall design |
Identification and characterization of membrane associated (MB) mitochondrial transcripts that are likely to be translated on the surface of mitochondria and those that seem to be synthesized by the free cytosolic polysomes (HS). Additionally, we noticed that proteostatic stress response triggered by the mia40a mutation in zebrafish causes accumulation of mRNAs encoding mitochondrial proteins in HS.
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| Contributor(s) |
Uszczynska-Ratajczak B, Sugunan S, Kwiatkowska M, Carbonell-Sala S, Migdał M, Guigo R, Winata CL, Chacinska A |
| Citation(s) |
36283702 |
| |
| Submission date |
Feb 26, 2021 |
| Last update date |
Nov 02, 2022 |
| Contact name |
Barbara Uszczyńska-Ratajczak |
| E-mail(s) |
buszczynska@ibch.poznan.pl
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| Organization name |
Institute of Bioorganic Chemistry, Polish Academy of Sciences
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| Lab |
Computational Biology of Noncoding RNA
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| Street address |
Noskowskiego 12/14
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| City |
Poznan |
| ZIP/Postal code |
61-704 |
| Country |
Poland |
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| Platforms (1) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA705081 |
| SRA |
SRP308331 |
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