|
| Status |
Public on Feb 26, 2021 |
| Title |
The stress response regulator HSF1 modulates natural killer cell anti-tumour immunity |
| Organisms |
Homo sapiens; Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Diverse cellular insults converge on activation of the heat shock factor 1 (HSF1), which regulates the proteotoxic stress response to maintain protein homoeostasis. HSF1 regulates numerous gene programmes beyond the proteotoxic stress response in a cell-type- and context-specific manner to promote malignancy. However, the role(s) of HSF1 in immune populations of the tumour microenvironment remain elusive. Here, we leverage an in vivo model of HSF1 activation and single-cell transcriptomic tumour profiling to show that augmented HSF1 activity in natural killer (NK) cells impairs cytotoxicity, cytokine production, and subsequent anti-tumour immunity. Mechanistically, HSF1 directly binds and regulates the expression of key mediators of NK cell effector function. This work demonstrates that HSF1 regulates the immune response under the stress conditions of the tumour microenvironment. These findings have important implications for enhancing the efficacy of adoptive NK cell therapies and for designing combinatorial strategies including modulators of NK cell-mediated tumour killing.
This SuperSeries is composed of the SubSeries listed below.
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| |
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| Overall design |
Refer to individual Series
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| |
|
| Contributor(s) |
Aifantis I, Kourtis N |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Feb 25, 2021 |
| Last update date |
Aug 04, 2024 |
| Contact name |
Kathryn Grace Hockemeyer |
| Organization name |
NYU Langone Health
|
| Department |
Pathology
|
| Lab |
Aifantis
|
| Street address |
550 1st Avenue
|
| City |
New York |
| State/province |
New York |
| ZIP/Postal code |
10016 |
| Country |
USA |
| |
|
| Platforms (2) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (21)
|
|
| This SuperSeries is composed of the following SubSeries:
|
| GSE167549 |
The NK cell stress response status modulates anti-tumor immunity [ATAC-seq] |
| GSE167550 |
The NK cell stress response status modulates anti-tumor immunity [RNA-seq] |
| GSE167551 |
The NK cell stress response status modulates anti-tumor immunity [scRNA-seq] |
| GSE194364 |
The NK cell stress response status modulates anti-tumor immunity [ChIP-seq] |
| GSE268176 |
The NK cell stress response status modulates anti-tumor immunity [ChIPmentation] |
|
| Relations |
| BioProject |
PRJNA704938 |
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