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| Status |
Public on Feb 19, 2024 |
| Title |
PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
As a tumor suppressor, PTEN is frequently mutated in human cancers and PTEN mutants promote tumor progression and metastasis. PTEN mutations have been implicated in immune regulation, but the underlying mechanism is largely unknown. We report that PTENα, the isoform of PTEN, remains active in cancer bearing stop-gained PTEN mutations. Through counteraction of CD8+ T cell-mediated cytotoxicity, presence of PTENα leads to T cell dysfunction and accelerates immune-resistant cancer progression. Clinical analysis further uncovers that PTENα-active mutations suppress host immune responses and result in poor prognosis in cancer as relative to PTENα-inactive mutations. Furthermore, germline deletion of Ptenα in mice increases cell susceptibility to immune attack through augmenting stress granule formation and limiting synthesis of peroxidases, leading to massive oxidative cell death and severe inflammatory damage. We propose that PTENα protects tumor from T cell killing and thus PTENα is a potential target in antitumor immunotherapy.
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| Overall design |
Study of tumor infiltration lymphocytes in Mock or PTENα expressing B16 Pten-/- tumors using 10x scRNA-seq technologies.
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| Contributor(s) |
Sun Y, Lu D, Zhang X |
| Citation missing |
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| Submission date |
Feb 24, 2021 |
| Last update date |
Feb 19, 2024 |
| Contact name |
Yizhe Sun |
| E-mail(s) |
sunyz1105@bjmu.edu.cn
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| Phone |
+8615811526996
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| Organization name |
Peking University Health Science Center
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| Street address |
No.38, Xueyuan Road ,Haidian District
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| City |
Beijing |
| State/province |
Beijing |
| ZIP/Postal code |
100191 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA704696 |
| SRA |
SRP307997 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE167469_RAW.tar |
37.2 Mb |
(http)(custom) |
TAR (of MTX, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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