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Series GSE167443 Query DataSets for GSE167443
Status Public on Apr 14, 2023
Title Sexual dimorphism in the response to chronic circadian misalignment (RNA-Seq)
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Longitudinal studies associate shiftwork with cardiometabolic disorders but do not establish causation nor elucidate mechanisms of disease. We developed a mouse model based on shiftwork schedules to study circadian misalignment in both sexes, where misaligned mice undergo an 8-hour phase advance every week for 15 weeks. Behavioral and transcriptional rhythmicity were preserved in female mice despite exposure to misalignment. Females were protected against the cardiometabolic impact of circadian disruption seen in males. The liver transcriptome and proteome revealed discordant pathway perturbations between the sexes. Tissue-level changes were accompanied by gut microbiome dysbiosis only in male mice. In the UK biobank, female shiftworkers showed stronger circadian rhythmicity in activity and a lower incidence of metabolic syndrome than males. Thus we show that female mice are resilient to chronic circadian misalignment, and that these differences are conserved in humans.
 
Overall design Liver mRNA profiles of male control, male misaligned, female control and female misaligned mice taken at 6 time points. Three biological replicates were analyzed per timepoint per group.
 
Contributor(s) Anderson ST, Meng H, Brooks TG, Tang SY, Nayak S, Mrčela A, Sarantopulou D, Grant GR, FitzGerald GA
Citation(s) 37196066
Submission date Feb 24, 2021
Last update date Jul 15, 2023
Contact name Antonijo Mrčela
Organization name University of Pennsylvania
Department Institute for Translational Medicine and Therapeutics
Street address 3400 Civic Center Boulevard
City Philadelphia
State/province Pennsylvania
ZIP/Postal code 19104-5158
Country USA
 
Platforms (1)
GPL21103 Illumina HiSeq 4000 (Mus musculus)
Samples (72)
GSM5105184 Female control at 00:00, replicate 1
GSM5105185 Female control at 00:00, replicate 2
GSM5105186 Female control at 00:00, replicate 3
This SubSeries is part of SuperSeries:
GSE222792 Sexual dimorphism in the response to chronic circadian misalignment
Relations
BioProject PRJNA704658
SRA SRP307965

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE167443_FINAL_master_list_of_exon_counts_MAX.antisense.PORT_result_Sean_data_Nov2019.txt.gz 1.8 Mb (ftp)(http) TXT
GSE167443_FINAL_master_list_of_exon_counts_MAX.sense.PORT_result_Sean_data_Nov2019.txt.gz 19.7 Mb (ftp)(http) TXT
GSE167443_FINAL_master_list_of_exon_counts_MIN.antisense.PORT_result_Sean_data_Nov2019.txt.gz 1.8 Mb (ftp)(http) TXT
GSE167443_FINAL_master_list_of_exon_counts_MIN.sense.PORT_result_Sean_data_Nov2019.txt.gz 19.4 Mb (ftp)(http) TXT
GSE167443_FINAL_master_list_of_gene_counts_MAX.antisense.PORT_result_Sean_data_Nov2019.txt.gz 658.6 Kb (ftp)(http) TXT
GSE167443_FINAL_master_list_of_gene_counts_MAX.sense.PORT_result_Sean_data_Nov2019.txt.gz 2.5 Mb (ftp)(http) TXT
GSE167443_FINAL_master_list_of_gene_counts_MIN.antisense.PORT_result_Sean_data_Nov2019.txt.gz 619.2 Kb (ftp)(http) TXT
GSE167443_FINAL_master_list_of_gene_counts_MIN.sense.PORT_result_Sean_data_Nov2019.txt.gz 2.3 Mb (ftp)(http) TXT
GSE167443_FINAL_master_list_of_intergenic_counts_MAX.PORT_result_Sean_data_Nov2019.txt.gz 642.9 Kb (ftp)(http) TXT
GSE167443_FINAL_master_list_of_intergenic_counts_MIN.PORT_result_Sean_data_Nov2019.txt.gz 492.3 Kb (ftp)(http) TXT
GSE167443_FINAL_master_list_of_intron_counts_MAX.antisense.PORT_result_Sean_data_Nov2019.txt.gz 2.3 Mb (ftp)(http) TXT
GSE167443_FINAL_master_list_of_intron_counts_MAX.sense.PORT_result_Sean_data_Nov2019.txt.gz 8.0 Mb (ftp)(http) TXT
GSE167443_FINAL_master_list_of_intron_counts_MIN.antisense.PORT_result_Sean_data_Nov2019.txt.gz 2.0 Mb (ftp)(http) TXT
GSE167443_FINAL_master_list_of_intron_counts_MIN.sense.PORT_result_Sean_data_Nov2019.txt.gz 7.7 Mb (ftp)(http) TXT
GSE167443_FINAL_master_list_of_junction_counts_MAX.PORT_result_Sean_data_Nov2019.txt.gz 19.2 Mb (ftp)(http) TXT
GSE167443_FINAL_master_list_of_junction_counts_MIN.PORT_result_Sean_data_Nov2019.txt.gz 19.1 Mb (ftp)(http) TXT
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Processed data are available on Series record

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