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Series GSE16675 Query DataSets for GSE16675
Status Public on Nov 17, 2010
Title The influence of segmental copy number variation on tissue transcriptomes through development
Organism Mus musculus
Experiment type Expression profiling by array
Summary A preliminary understanding of the phenotypic effect of copy number variation (CNV) of DNA segments is emerging. These rearrangements were demonstrated to influence, in a somewhat dose-dependent manner, the expression of genes mapping within. They were shown to also affect the expression of genes located on their flanks, sometimes at great distance. Here, we show by monitoring these effects at multiple life stages, that these controls over expression are effective throughout mouse development. Similarly, we observe that the more specific spatial expression patterns of CNV genes are maintained throughout life. However, we find that some brain-expressed genes appear to be under compensatory loops only at specific time-points, indicating that the influence of CNVs on these genes is modulated through development. We also observe that CNV genes are significantly enriched upon transcripts that show variable time-course of expression in different strains. Thus modifying the number of copy of a gene not only potentially alters its expression level, but possibly also its time of expression.

Keywords: comparative genomic
Overall design Expression from brain and liver tissues from C57BL/6J, DBA2/J and 129S2 mouse strains at different developmental time points.
Contributor(s) Chaignat E, Pradervand S, Aït Yahya-Graison E, Henrichsen CN, Chrast J, Reymond A
Citation(s) 21084671
Submission date Jun 17, 2009
Last update date Feb 11, 2019
Contact name Sylvain Pradervand
Phone +41 21 692 39 08
Organization name UNI Lausanne
Department CIG
Lab DNA Array Facility
Street address Genopode
City Lausanne
ZIP/Postal code 1015
Country Switzerland
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (72)
GSM417900 129_E14.5_brain_rep1
GSM417901 129_E14.5_brain_rep2
GSM417902 129_E14.5_brain_rep3
BioProject PRJNA117393

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Supplementary file Size Download File type/resource
GSE16675_RAW.tar 450.8 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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