|
| Status |
Public on Aug 02, 2021 |
| Title |
CD93+ and CD93- HSCs comparison [RNA-Seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Hematopoietic stem cells (HSCs) are characterized by their ability to generate all blood cells while retaining their self-renewal capacity. While it is convenient to believe that HSCs represent a homogenous population, several evidences do not support this notion. Here we identified and characterized a HSC population that expressed CD93 on their membrane. This population showed strong molecular dHSC signature, combined with activation features. Thereby, suggesting that they represent an intermediate state between quiescent and active HSCs being more prone to respond upon alterations in the hematopoietic lineage
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| |
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| Overall design |
Bulk RNA seq from sorted HSC (LSK+CD34-CD48-Flt3-Slam1+) CD93+ or CD93-
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| |
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| Contributor(s) |
Akhtar A, Rodrigues CP |
| Citation(s) |
34362741 |
| |
| Submission date |
Feb 09, 2021 |
| Last update date |
Aug 18, 2021 |
| Contact name |
Asifa Akhtar |
| E-mail(s) |
akhtarlab_data@ie-freiburg.mpg.de
|
| Organization name |
Max Planck Institute of Immunobiology and Epigenetics
|
| Department |
Chromatin Regulation
|
| Lab |
Akhtar Lab
|
| Street address |
Stuebeweg 51
|
| City |
Freiburg |
| ZIP/Postal code |
79108 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (6)
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| This SubSeries is part of SuperSeries: |
|
| Relations |
| BioProject |
PRJNA701026 |
| SRA |
SRP305534 |
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