NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE166361 Query DataSets for GSE166361
Status Public on Apr 05, 2021
Title Regulatory neutrophil transcriptional profiling
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We report that pharmacologically-induced autoantigen-specific T-regulatory type 1 (TR1) cells and TR1 cell-induced B-regulatory (Breg) cells recruit neutrophils into the liver and program their transcriptome to generate regulatory neutrophils
 
Overall design We defined the transcriptional profile of neutrophils from liver and blood of pMHC-NP-treated and untreated NOD.c3c4 mice to define the transcriptional make-up defining the disease-regulatory nature of the liver neutrophils that arise in treated mice. We also studied the transcriptional changes in these liver regulatory neutrophils upon pMHC-NP therapy in the presence/absence of cytokine-blocking antibodies.
 
Contributor(s) Santamaria P, Solé P
Citation(s) 33789099
Submission date Feb 08, 2021
Last update date Apr 05, 2021
Contact name Pere Santamaria
E-mail(s) pesantam@clinic.cat
Organization name IDIBAPS
Street address C/Rosselló 149-153
City Barcelona
ZIP/Postal code 08036
Country Spain
 
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (24)
GSM5069013 Blood_Neutrophil_Untreated_rep1
GSM5069014 Blood_Neutrophil_Untreated_rep2
GSM5069015 Blood_Neutrophil_Untreated_rep3
Relations
BioProject PRJNA700601
SRA SRP305324

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE166361_Raw_counts_Cytokines.xlsx 2.0 Mb (ftp)(http) XLSX
GSE166361_Raw_counts_Liver_Blood.xlsx 1.9 Mb (ftp)(http) XLSX
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap