Expression profiling by high throughput sequencing
Summary
We report that pharmacologically-induced autoantigen-specific T-regulatory type 1 (TR1) cells and TR1 cell-induced B-regulatory (Breg) cells recruit neutrophils into the liver and program their transcriptome to generate regulatory neutrophils
Overall design
We defined the transcriptional profile of neutrophils from liver and blood of pMHC-NP-treated and untreated NOD.c3c4 mice to define the transcriptional make-up defining the disease-regulatory nature of the liver neutrophils that arise in treated mice. We also studied the transcriptional changes in these liver regulatory neutrophils upon pMHC-NP therapy in the presence/absence of cytokine-blocking antibodies.
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