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Series GSE165395 Query DataSets for GSE165395
Status Public on Feb 27, 2022
Title Dissecting the stem cell compartment in Csnk1a1 haploinsufficiency
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We sorted hematopoietic progenitors from mouse bone marrow previously transplanted with either Csnk1a1 fl/+ or Mx1Cre+ bone marrow and performed scRNAseq. We identified cell populations in a continuum of differentiation from quiescent stem cell to cycling lineage-marker expressing progenitor. Our analysis revealed signaling changes in primitive stem cells with Csnk1a1 haploinsufficiency that result in downregulation of inflammatory NFkB signaling while upregulating Myc and E2f dependent pro-proliferative pathways
Overall design We used scRNA 3' RNA sequencing product from 10x Genomics to investigate the stem cell compartment in murine models of Csnk1a1 haploinsufficiency
Contributor(s) Stalmann US, i Li R, Costa IG, Schneider RK
Citation(s) 35016204
Submission date Jan 24, 2021
Last update date Mar 01, 2022
Contact name Ronghui Li
Organization name RWTH Aachen
Lab nstitute for Computational Genomics
Street address Pauwelsstr. 19
City Aachen
ZIP/Postal code 52074
Country Germany
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (7)
GSM5032749 Csnk_35_3LSK
GSM5032750 Csnk_35_4LSK
GSM5032751 MxCre_35_2LSK
BioProject PRJNA694424
SRA SRP303017

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE165395_RAW.tar 4.4 Gb (http)(custom) TAR (of H5)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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