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| Status |
Public on May 11, 2021 |
| Title |
H3K9-butyryl (H3K9Bu) and H3K9-acetyi (H3K9ac) genome patterns before and after transverse aortic constriction in Balb/cJ and Balc/cByJ mice |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
Balb/cJ mice on a low-fat diet show a decline in promoter H3K9-butyryl (H3K9Bu) in the heart, after subjecting them to transverse aortic constriction (TAC). In contrast, Balb/cByJ, which has a deletion in the ACADS gene, exhibit an increase in promoter H3K9Bu. Conversely, H3K9ac increases in the former and declines in the latter.
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| Overall design |
Balb/cJ and Balb/cByJ mice were fed either a low-fat (10 Kcal%) diet for 4 days before subjecting them to a sham or transverse aortic constriction (TAC) surgeries. The mice were maintained on the same diet for another week, before they were assessed by echocardiography, the hearts isolated, chromatin extracted , and subjected to anti-H3K9Bu and anti-H3K9ac ChIP-Seq
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| Contributor(s) |
Adellatif M |
| Citation(s) |
33989779 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R01 HL146537 |
Transcriptional mechanisms in cardiac hypertrophy |
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY--RBHS-NEW JERSEY MEDICAL SCHOOL |
Maha Abdellatif |
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| Submission date |
Jan 21, 2021 |
| Last update date |
Jun 28, 2021 |
| Contact name |
Maha Abdellatif |
| E-mail(s) |
abdellma@njms.rutgers.edu
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| Phone |
9739721254
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| Organization name |
Rutgers-University
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| Department |
Cell Biology and Molecular Medicine
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| Street address |
185 S. Orange Ave.
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| City |
Newark |
| State/province |
NJ |
| ZIP/Postal code |
07103 |
| Country |
USA |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA693852 |
| SRA |
SRP302744 |
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