|
| Status |
Public on May 26, 2021 |
| Title |
Induction of an Interferon Response Program in EGFR Mutant Lung Cancer by Tyrosine Kinase Inhibitors Positively Associates with Clinical Response |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The goal of this study was to analyze rapid transcriptional responses induced by TKIs early in treatment that associate with the range of patient responses observed to oncogene specific inhibitors.
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| |
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| Overall design |
RNA-seq was used to define transcriptional changes that occur in response to EGFR TKI in human lung cancer cell lines PC9, H1650, HCC4006, and H1975 and human 8 matched lung tumor biopsies.
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| |
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| Contributor(s) |
Gurule N, McCoach C, Hinz T, Merrick D, Van Bokhoven A, Kim J, Patil T, Calhoun J, Nemenoff R, Tan AC, Doebele R, Heasley L |
| Citation(s) |
34001994 |
| |
| Submission date |
Jan 18, 2021 |
| Last update date |
May 26, 2021 |
| Contact name |
Natalia J Gurule |
| E-mail(s) |
natalia.gurule@cuanschutz.edu
|
| Organization name |
University of Colorado Anschutz Medical Campus
|
| Department |
Craniofacial Biology
|
| Lab |
Lynn Heasley Lab
|
| Street address |
12801 E 17th ave
|
| City |
Aurora |
| State/province |
CO |
| ZIP/Postal code |
80045 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (71)
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| Relations |
| BioProject |
PRJNA692976 |
| SRA |
SRP302192 |
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