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Series GSE16363 Query DataSets for GSE16363
Status Public on Jun 02, 2009
Title Microarray Analysis of Lymphatic Tissue Reveals Stage-Specific, Gene-Expression Signatures in HIV-1 Infection
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Untreated HIV-1 infection progresses through acute and asymptomatic stages to AIDS. While each of the three stages has well-known clinical, virologic and immunological characteristics, much less is known of the molecular mechanisms underlying each stage. Here we report lymphatic tissue microarray analyses revealing for the first time stage-specific patterns of gene expression during HIV-1 infection. We show that while there is a common set of key genes with altered expression throughout all stages, each stage has a unique gene-expression signature. The acute stage is most notably characterized by increased expression of hundreds of genes involved in immune activation, innate immune defenses (e.g.MDA-5, TLR-7 and -8, PKR, APOBEC3B, 3F, 3G), adaptive immunity, and in the pro-apoptotic Fas-Fas-L pathway. Yet, quite strikingly, the expression of nearly all acute-stage genes return to baseline levels in the asymptomatic stage, accompanying partial control of infection. In the AIDS stage, decreased expression of numerous genes involved in T cell signaling identifies genes contributing to T cell dysfunction. These common and stage-specific, gene-expression signatures provide new insights into the molecular mechanisms underlying the host response and the slow, natural course of HIV-1 infection.
Overall design A total of 52 patients were analyzed: 10 patients unaffected, 18 patients with asymptomatic stages of AIDs, 16 patients with acute stages of AIDs, and 8 patients with AIDs.
Contributor(s) Li Q, Smith AJ, Schacker TW, Carlis JV, Duan L, Reilly CS, Haase AT
Citation(s) 19596987, 21525393
Submission date Jun 01, 2009
Last update date Mar 25, 2019
Contact name qingsheng li
Phone 612-624-9130
Fax 612-626-0623
Organization name University of Minnesota
Department Microbiology
Lab Ashley T. Haase
Street address Box 196, 420 Delaware ST SE
City minneapolis
State/province MN
ZIP/Postal code 55455
Country USA
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (52)
GSM410750 AP760a
GSM410751 AP760b
GSM410752 CF630b
BioProject PRJNA115319

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Supplementary file Size Download File type/resource
GSE16363_RAW.tar 448.3 Mb (http)(custom) TAR (of CEL)
GSE16363_further_processed data.xls.gz 4.0 Mb (ftp)(http) XLS
Processed data included within Sample table

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