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Series GSE163366 Query DataSets for GSE163366
Status Public on Dec 17, 2020
Title Analysis of the microbiota composition of colorectal mucosa tissues and adjacent healthy tissues of 40 patients affected by colorectal cancer.
Organism Homo sapiens
Experiment type Other
Summary Colorectal cancer is a chronic inflammation-associated tumor and the immune system, besides protecting the host from developing tumors, can support the CRC progression. In this scenario, due to its capability to elicit the production of cytokines, gut microbiota is essential to modulate immune response, influencing immunostimulatory or immunosuppressive reactions. So, the investigation of the microbiota-immunity axis in healthy and tumor mucosa is crucial to well understand the cancer development with positive relapses in prevention and treatment.
 
Overall design Total DNA was extracted from tumoral and surrounding healthy mucosa samples of 40 patients affected by colorectal cancer CRC patients and amplicons of variable V3–V4 regions of the bacterial 16s rRNA gene were sequenced.
 
Contributor(s) Ramazzotti M, Amedei A
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Submission date Dec 16, 2020
Last update date Dec 21, 2020
Contact name Matteo Ramazzotti
E-mail(s) matteo.ramazzotti@unifi.it
Organization name University of Florence
Department Experimental and Clinical Biomedical Sciences
Street address viale Morgagni 50
City Firenze
ZIP/Postal code 50134
Country Italy
 
Platforms (1)
GPL15520 Illumina MiSeq (Homo sapiens)
Samples (80)
GSM4977617 colorectal mucosa of sample CRC.1
GSM4977618 healthy tumor-surrounding mucosa of sample CRC.1
GSM4977619 colorectal mucosa of sample CRC.3
Relations
BioProject PRJNA685827
SRA SRP298228

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE163366_RAW.tar 290.5 Mb (http)(custom) TAR (of FASTA)
GSE163366_otu_tax.txt.gz 74.3 Kb (ftp)(http) TXT
GSE163366_otus_sel.fasta.gz 187.0 Kb (ftp)(http) FASTA
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record
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