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Series GSE16334 Query DataSets for GSE16334
Status Public on Sep 15, 2009
Title Expression data from normal and Fanconi anemia low density bone marrow cells
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Fanconi anemia (FA) is a rare inherited disease complicated by aplastic anemia. There is evidence that hematopoietic stem cells have lost self replicative capacity and undergo apoptosis when exposed to inhibitory cytokines including interferon gamma and tumor necrosis factor-alpha.
We used gene expression microarrays to identify transcriptomal differences between bone marrow cells from normal volunteers and from children and adults with Fanconi anemia
Overall design Fanconi anemia patients were identified using mitomycin C and/or diepoxybutane chromosomal breakage analysis. Eleven normal volunteers and 21 FA patients were studied. All FA patients with cytogenetic evidence of clonal evolution were excluded. All FA patients with acute leukemia were excluded. RNA was prepared from freshly obtained low density mononuclear cell fractions.
Contributor(s) Bagby GC, Yates J
Citation(s) 19850743
Submission date May 28, 2009
Last update date Aug 10, 2018
Contact name Grover C Bagby, MD
Organization name Oregon Health & Science University
Department Dept. of Medicine
Lab Knight Cancer Institute
Street address 3181 SW Sam Jackson Park Rd.
City Portland
State/province OR
ZIP/Postal code 97239
Country USA
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (32)
GSM409696 10051_normal control_rep1
GSM409697 10071_normal control_rep2
GSM409698 10091_normal control_rep3
BioProject PRJNA115229

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Supplementary file Size Download File type/resource
GSE16334_RAW.tar 211.5 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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