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| Status |
Public on Dec 14, 2023 |
| Title |
Expression data from ageing wt N2 Bristol Caenorhabditis elegans population. |
| Organism |
Caenorhabditis elegans |
| Experiment type |
Expression profiling by array
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| Summary |
The determination of molecular pathways that are affected with age and lead to increased disease susceptibility is crucial. The nematode has proven an ideal experimental model to study ageing due to significantly conserved genes governing ageing throughout species. Profiling of gene expression levels in ageing wt Caenorhabditis elegans, utilizing a robust Affymetrix microarray platform, resulted in the identification of age-dependent gene expression alterations that characterize the nematode's ageing process.
We used Affymetrix microarrays to detail the global programme of gene expression underlying ageing and identified distinct classes of up- or down-regulated genes during this process.
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| Overall design |
We profiled gene expression levels of wt C. elegans population of three ageing time-points, in biological triplicates for young (Day 1) and middle aged (Day 6) ones and biological duplicates for old worms (Day 12) using the Affymetrix GeneChip™ C. elegans Gene 1.1 ST Array Platform.
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| Contributor(s) |
Chondrogianni N, Grune T, Aktypi F |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Dec 15, 2020 |
| Last update date |
Dec 14, 2023 |
| Contact name |
Niki Chondrogianni |
| E-mail(s) |
nikichon@eie.gr
|
| Organization name |
National Hellenic Research Foundation
|
| Department |
ICB - Institute of Chemical Biology
|
| Lab |
Chondrogianni
|
| Street address |
Leof. Vasileos Konstantinou 48
|
| City |
Athens |
| State/province |
Attiki |
| ZIP/Postal code |
11635 |
| Country |
Greece |
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| Platforms (1) |
| GPL28002 |
[EleGene-1_1-st] Affymetrix C. elegans Gene 1.1 ST Array [transcript (gene) version] |
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| Samples (8)
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| GSM4975745 |
adult population at day 1 of adulthood, biological rep1 |
| GSM4975746 |
adult population at day 1 of adulthood, biological rep2 |
| GSM4975747 |
adult population at day 1 of adulthood, biological rep3 |
| GSM4975748 |
adult population at day 6 of adulthood, biological rep1 |
| GSM4975749 |
adult population at day 6 of adulthood, biological rep2 |
| GSM4975750 |
adult population at day 6 of adulthood, biological rep3 |
| GSM4975751 |
adult population at day 12 of adulthood, biological rep1 |
| GSM4975752 |
adult population at day 12 of adulthood, biological rep2 |
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| Relations |
| BioProject |
PRJNA685423 |
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