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| Status |
Public on Mar 22, 2021 |
| Title |
IGF2BP1, a conserved regulator of RNA turnover in cancer [total RNA] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The IGF2 mRNA binding protein 1 (IGF2BP1) promotes tumor progression in a multitude of solid tumors and its expression is associated with adverse prognosis. The main role proposed for IGF2BP1 in cancer cells is the stabilization of mRNAs encoding pro-oncogenic factors. Several binding studies, however, revealed a plethora of putative IGF2BP1-RNA targets. Thus, at present the main, conserved target RNAs and pathways controlled by IGF2BP1 in cancer remain elusive. In this study, we present a set of genes showing a conserved pattern of deregulation in dependence of IGF2BP1 expression in cancer-derived cell lines. By incorporating publicly available data sets, we further compiled a set of RNAs probably stabilized by IGF2BP1 in cancer and characterized them. Functional enrichment analyses revealed conserved pathways influenced by IGF2BP1 in cancer.
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| Overall design |
Total RNA-Seq of different solid tumor-derived cells transfected with either control siRNAs (siC) or siRNAs directed against IGF2BP1. Three replicates per condition.
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| Contributor(s) |
Glaß M, Misiak D, Bley N, Müller S, Hagemann S, Hüttelmaier S |
| Citation(s) |
33829040 |
| |
| Submission date |
Nov 09, 2020 |
| Last update date |
Apr 13, 2021 |
| Contact name |
Markus Glaß |
| E-mail(s) |
markus.glass@medizin.uni-halle.de
|
| Organization name |
Martin Luther University Halle-Wittenberg
|
| Department |
Institute of Molecular Medicine
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| Lab |
Huettelmaier Lab
|
| Street address |
Kurt-Mothes-Str. 3a
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| City |
Halle |
| ZIP/Postal code |
06120 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (24)
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| This SubSeries is part of SuperSeries: |
| GSE161101 |
IGF2BP1, a conserved regulator of RNA turnover in cancer |
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| Relations |
| BioProject |
PRJNA675536 |
| SRA |
SRP291710 |
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