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Series GSE16098 Query DataSets for GSE16098
Status Public on Oct 13, 2009
Title Genome-wide analysis of genes regulated transcriptionally and post-transcriptionally by HTLV-I p30
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The Human T-cell Leukemia Virus (HTLV)-type-I non-structural protein p30 plays an important role in virus transmission and gene regulation. p30 has been documented to inhibit the export of certain viral mRNA transcripts from the nucleus to the cytoplasm. This nuclear retainment of RNA molecules essentially results in gene silencing, where protein products are not produced.
Considering this unique function of p30, we used microarray analysis to assess the ability of p30 to inhibit not only the regulation of transcription of cellular genes, but also the ability of p30 to regulate the export of cellular transcripts to the cytoplasm.
Overall design Total or cytoplamsic RNA from peripheral blood mononuclear cells expressing HTLV-I p30 was isolated and analyzed by microarray analysis, in comparison with mock-transcuced cells.
Contributor(s) Nicot C, Ghorbel S, Taylor JM
Citation(s) 19602286
Submission date May 13, 2009
Last update date Mar 25, 2019
Contact name Christophe Nicot
Organization name University of Kansas Medical Center
Department Pathology and Lab Medicine
Street address 3901 Rainbow Blvd.
City Kansas City
State/province KS
ZIP/Postal code 66160
Country USA
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (4)
GSM402875 PBMC Total RNA
GSM402876 PBMC Cytoplasmic RNA
GSM402877 PBMC p30 Total RNA
BioProject PRJNA115465

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Supplementary file Size Download File type/resource
GSE16098_RAW.tar 43.3 Mb (http)(custom) TAR (of CEL, CHP)
Raw data provided as supplementary file
Processed data included within Sample table
Processed data provided as supplementary file

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