|
| Status |
Public on Feb 01, 2021 |
| Title |
SARS-CoV-2 infection of human pancreatic islets |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We performed RNA-sequencing in uninfected, SARS-CoV-2-infected, and additionally remdesivir treated ex vivo cultured human islets from two donors to shed light on the transcriptional changes occurring upon viral infection.
|
| |
|
| Overall design |
Islet preparations of two different donors were infected with SARS-CoV-2 and treated with Remdesivir for 5 days. Uninfected pancreatic islets served as control.
|
| |
|
| Contributor(s) |
Heller S, Groß R, Conzelmann C, Müller JA, Krüger J, Schuster M, Breunig M, Münch J, Kleger A |
| Citation(s) |
33536639 |
| |
| Submission date |
Oct 20, 2020 |
| Last update date |
Feb 05, 2021 |
| Contact name |
Alexander Kleger |
| E-mail(s) |
alexander.kleger@uni-ulm.de
|
| Organization name |
Ulm University
|
| Street address |
Albert Einstein Allee 23
|
| City |
Ulm |
| ZIP/Postal code |
89160 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
|
| Samples (6)
|
| GSM4838433 |
Human pancreatic islets - Control - experiment 2 |
| GSM4838434 |
Human pancreatic islets - SARS-Cov-2 and Remdesivir - experiment 2 |
| GSM4838435 |
Human pancreatic islets - SARS-Cov-2 - experiment 2 |
| GSM4838436 |
Human pancreatic islets - Control - experiment 3 |
| GSM4838437 |
Human pancreatic islets - SARS-Cov-2 and Remdesivir - experiment 3 |
| GSM4838438 |
Human pancreatic islets - SARS-Cov-2 - experiment 3 |
|
| Relations |
| BioProject |
PRJNA670242 |
| SRA |
SRP287872 |
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