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Series GSE159488 Query DataSets for GSE159488
Status Public on Jan 14, 2021
Title A versatile platform for locus-scale genome rewriting and verification
Organisms Homo sapiens; Mus musculus; synthetic construct
Experiment type Other
Summary Sequencing data supporting the Big-IN method for targeted delivery of large DNA constructs to mammalian cells.
Overall design WGS and Capture-seq data from cell lines engineered to harbor landing pads (LPs) at the HPRT1 locus in human ESCs and two different loci in mouse ESCs, and various payloads subsequently delivered to these LPs.
Contributor(s) Brosh R, Laurent JM, Ordoñez R, Huang E, Hogan MS, Hitchcock AM, Mitchell LA, Pinglay S, Cadley JA, Luther RD, Boeke JD, Maurano MT
Citation(s) 33649239
Submission date Oct 13, 2020
Last update date Mar 23, 2021
Contact name Mathew T Maurano
Organization name NYU Langone Health
Department Institute for Systems Genetics
Lab Maurano Lab
Street address 435 E 30th St
City New York
State/province NY
ZIP/Postal code 10016
Country USA
Platforms (4)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
GPL19057 Illumina NextSeq 500 (Mus musculus)
GPL19424 Illumina NextSeq 500 (synthetic construct)
Samples (44)
GSM4830880 BL6xC-mESCs-Parental-BS06877A
GSM4830881 BL6xC-mESCs-LP-PIGA-A1-BS07003A
GSM4830882 Failed-BL6xC-mESCs-LP-PIGA-Clone-BS03022A
BioProject PRJNA669046
SRA SRP287294

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE159488_RAW.tar 23.0 Gb (http)(custom) TAR (of BW)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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