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Series GSE159201 Query DataSets for GSE159201
Status Public on Apr 20, 2021
Title iPSC-derived Human Intestinal Organoids are permissive to SARS-CoV-2 infection
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We performed transcriptomic profiling of cells derived from human induced pluripotent stem cells (iPSCs) using a directed differentiation protocol to generate mesenchyme free, regionally patterned intestinal organoids. These organoids were then infected with SARS-CoV-2, and sequencing was performed 1 and 4 days post infection
 
Overall design Global transcriptomic analysis of PSC-derived intestinal organoids infected with SARS-CoV-2 omparing 1 and 4 days post infection to matched mock controls in both proximal and distally patterned infestinal organoids. (n=3 per condition)
 
Contributor(s) Mithal A, Lindstrom-Vautrin J, Villacorta-Martin C, Mostoslavsky G
Citation(s) 33852884
Submission date Oct 07, 2020
Last update date Apr 20, 2021
Contact name Carlos Villacorta-Martin
Organization name Center for Regenerative Medicine at Boston University
Street address 670 Albany St
City Boston
State/province MA
ZIP/Postal code 02118
Country USA
 
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (24)
GSM4822509 Day 90 organoids Colonic Mock 1DPI Rep 1
GSM4822510 Day 90 Organoids colonic Mock 1DPI Rep 2
GSM4822511 Day 90 organoids Colonic Mock 1DPI Rep 3
Relations
BioProject PRJNA667939
SRA SRP286669

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Supplementary file Size Download File type/resource
GSE159201_cpm.csv.gz 3.3 Mb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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