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Series GSE158884 Query DataSets for GSE158884
Status Public on Jun 04, 2021
Title RNA-seq in HepG2 cells with YY1 knockdown
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Dysregulation of YY1 has been observed in many human cancers. Recent studies have shown that overexpression of YY1 plays a pivotal role in the initiation and progression of nonalcoholic fatty liver disease (NAFLD) which may further progress into hepatocellular carcinoma (HCC). To obtain a detailed view of genes and pathways regulated by YY1 in the liver, we carried out global RNA-seq in liver HepG2 cells with YY1 knocked down.
 
Overall design The expression of YY1 was knocked down by lentiviral-mediated short-hairpin RNAs (shRNAs) and artificial miRNA (amiRNA). The RNA-seq was carried out in HepG2 cells with YY1 knockdown (n=8) and the HepG2 cells tranduced with the control virus (n=14).
 
Contributor(s) Wadelius C, Pan G
Citation(s) 34099540
Submission date Oct 01, 2020
Last update date Jun 09, 2021
Contact name Claes Wadelius
E-mail(s) claes.wadelius@igp.uu.se
Phone 46184714076
Organization name Uppsala universitet
Department Immunology, Genetics and Pathology
Street address Husargatan 3 PO BOX 815, BMC B11:4
City Uppsala
State/province Uppsala
ZIP/Postal code 75237
Country Sweden
 
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (22)
GSM4813878 HepG2-control-rep1
GSM4813879 HepG2-control-rep2
GSM4813880 HepG2-control-rep3
Relations
BioProject PRJNA666897
SRA SRP286033

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE158884_YY1_KD_feature_counts.txt.gz 750.1 Kb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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