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| Status |
Public on Dec 31, 2022 |
| Title |
Polycomb complexes in skin epithelium development II |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
Polycomb group (PcG) proteins are essential epigenetic transcriptional regulators. Traditionally, PcG proteins function as two multi-subunit complexes, Polycomb repressive complex 1 (PRC1) and PRC2, which largely overlap in their genomic binding and cooperate to establish repressive chromatin domains demarcated by H2AK119ub and H3K27me3. Here, using the developing skin epidermis as a paradigm, we uncovered a functional redundancy between Polycomb complexes in the repression of unwanted non-lineage genes.
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| Overall design |
Newborn mouse epidermal progenitor cells were FACS purified. Immunoprecipitated chromatin was analyzed by ChIP-seq.
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| Contributor(s) |
Cohen I, Zheng D, Ezhkova E |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Sep 21, 2020 |
| Last update date |
Dec 31, 2022 |
| Contact name |
Deyou Zheng |
| E-mail(s) |
deyou.zheng@einsteinmed.edu
|
| Organization name |
Albert Einstein College of Medicine
|
| Street address |
1300 Morris Park Ave
|
| City |
Bronx |
| State/province |
NY |
| ZIP/Postal code |
10461 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (7)
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| This SubSeries is part of SuperSeries: |
| GSE158324 |
Polycomb complexes in skin epithelium development |
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| Relations |
| BioProject |
PRJNA664807 |
| SRA |
SRP284318 |
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