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| Status |
Public on Oct 06, 2021 |
| Title |
Fetal brain elicits sexually conflicting transcriptional response to the deficiency of uterine Forkhead Box A2 (Foxa2) in mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
RNA-seq identified different gene sets relating to biological functions such as aging, longevity, and nutrient sensing and signaling that were regulated in a sex-biased manner between the placenta and fetal brain. Conditional knockout of the transcription factor Forkhead Box A2 (Foxa2) in the uterus elicited sexual conflicting expression of those genes between the placenta and fetal brain.
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| Overall design |
The day 15 placenta and brain of male and female fetuses of wild-type (C57BL/6) mice and mice deficent of uterine Foxa2 were analyzed by RNA-seq.
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| Contributor(s) |
Dhakal P, Strawn M, Samal A, Behura SK |
| Citation(s) |
34575858, 38334607 |
| |
| Submission date |
Sep 06, 2020 |
| Last update date |
Feb 15, 2024 |
| Contact name |
Susanta K. Behura |
| E-mail(s) |
behuras@missouri.edu
|
| Organization name |
Univeristy of Missouri
|
| Department |
Division of Animal Sciences
|
| Street address |
920 East Campus Drive
|
| City |
Columbia |
| State/province |
Missouri |
| ZIP/Postal code |
65211 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (24)
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| This SubSeries is part of SuperSeries: |
| GSE157556 |
Insights into the regulation of the brain-placental axis |
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| Relations |
| BioProject |
PRJNA661737 |
| SRA |
SRP280272 |
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