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Series GSE157240 Query DataSets for GSE157240
Status Public on Oct 07, 2021
Title RNAseq analysis of blood from respiratory viruses-infected patients and healthy controls
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary The objective of this study was to understand the shared and unique elements of the host transcriptional response to different viral pathogens. We identified 162 subjects in the US and Sri Lanka with infections due to influenza, enterovirus/rhinovirus, human metapneumovirus, dengue virus, cytomegalovirus, Epstein Barr Virus, or adenovirus. Our dataset allowed us to identify common pathways at the molecular level as well as virus-specific differences in the host immune response. Conserved elements of the host response to these viral infections high-lighted the importance of interferon pathway activation. However, the magnitude of the re-sponses varied between pathogens. We also identified virus-specific responses to influenza, enterovirus/rhinovirus, and dengue infections.
 
Overall design Peripheral blood was collected from patients, RNA was isolated and sequenced.
 
Contributor(s) Schughart K
Citation(s) 34777354
Submission date Sep 01, 2020
Last update date Nov 18, 2021
Contact name Klaus Schughart
E-mail(s) labschughart@online.de
Phone +49-159-0483-7911
Organization name University Münster
Department Virology
Street address Von-Esmarch-Str 56
City Münster
ZIP/Postal code 48149
Country Germany
 
Platforms (1)
GPL20301 Illumina HiSeq 4000 (Homo sapiens)
Samples (187)
GSM4759806 DU09.02S12199
GSM4759807 DU09.02S12209
GSM4759808 DU09.02S14204
Relations
BioProject PRJNA660611
SRA SRP279559

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE157240_sbst1_norm_RVI_Tsalik_020420.txt.gz 14.5 Mb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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