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| Status |
Public on Aug 28, 2020 |
| Title |
Transcriptomic analysis of peripheral blood mononuclear cells (PBMC) of patients with type 2 Diabetes Melittus(T2DM), Dyslipidemia (DL) and Periodontitis (P) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We identified that PBMC of individuals simultaneously affected by a combination of T2DM, dyslipidemia and periodontitis, showed altered molecular profile mainly associated to inflammatory response, immune cell trafficking, and infectious disease pathways
Patients were divided into: T2DMpoorly-DL-P (n=5, Grupo 1), T2DMwell-DL-P (n=7, Grupo 2), DL-P (n=6, Grupo 3), P (n=6, Grupo 4) and Healthy (n=6, Control). T2DM poorly controlled = HbA1c ≥8.5%; T2DM well-controlled patients = HbA1c <7.0%
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| Overall design |
PBMC were collected from 150 patients divided into 5 groups, the RNA was extracted using the Trizol® and purified by RNeasy Protection Mini Kit. It was used the GeneChip IVT Labeling Kit protocol and hybridized to U133 Plus 2.0 (Affymetrix)
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| Contributor(s) |
Scarel-Caminaga RM, Corbi SC, Maurer-Morelli C, Orrico SR, Rocha C |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Aug 27, 2020 |
| Last update date |
Aug 30, 2020 |
| Contact name |
Cristiane de Souza Rocha |
| Organization name |
Unicamp
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| Department |
Medical Genetics
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| Street address |
Av Tessália Vieira de Camargo, 126 Cidade Universitária "Zeferino Vaz"
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| City |
Campinas |
| State/province |
São Paulo |
| ZIP/Postal code |
13083-887 |
| Country |
Brazil |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (30)
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| GSM4749819 |
T2DMpoorly-DL-P, biological rep4 |
| GSM4749820 |
T2DMpoorly-DL-P, biological rep5 |
| GSM4749821 |
T2DMwell-DL-P, biological rep1 |
| GSM4749822 |
T2DMwell-DL-P, biological rep2 |
| GSM4749823 |
T2DMwell-DL-P, biological rep3 |
| GSM4749824 |
T2DMwell-DL-P, biological rep4 |
| GSM4749825 |
T2DMwell-DL-P, biological rep5 |
| GSM4749826 |
T2DMwell-DL-P, biological rep6 |
| GSM4749827 |
T2DMwell-DL-P, biological rep7 |
| GSM4749828 |
DL-P, biological rep1 |
| GSM4749829 |
DL-P, biological rep2 |
| GSM4749830 |
DL-P, biological rep3 |
| GSM4749831 |
DL-P, biological rep4 |
| GSM4749832 |
DL-P, biological rep5 |
| GSM4749833 |
DL-P, biological rep6 |
| GSM4749834 |
P, biological rep1 |
| GSM4749835 |
P, biological rep2 |
| GSM4749836 |
P, biological rep3 |
| GSM4749837 |
P, biological rep4 |
| GSM4749838 |
P, biological rep5 |
| GSM4749839 |
P, biological rep6 |
| GSM4749840 |
H, biological rep1 |
| GSM4749841 |
H, biological rep2 |
| GSM4749842 |
H, biological rep3 |
| GSM4749843 |
H, biological rep4 |
| GSM4749844 |
H, biological rep5 |
| GSM4749845 |
H, biological rep6 |
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| Relations |
| BioProject |
PRJNA659741 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE156993_RAW.tar |
101.5 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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