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| Status |
Public on Aug 22, 2020 |
| Title |
Gamma-secretase inhibition does not affect gene expression in squamous cell carcinoma cells that do not express Notch1 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
As part of a larger study on the role of Notch1 activation in squamous cell carcinoma (SCC), these control data sets were generated to study the effect of gamma-secretase inhibition on SCC cells that do not express Notch1. We found that no genes are significantly changed in response to gamma-secretase inhibition.
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| Overall design |
IC8 squamous cell carcinoma cells were grown in the presence or absence of gamma secretase inhibitor for 24 hours. Two replicates of each condition were performed.
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| |
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| Contributor(s) |
Rogers JM, Blacklow SC, Aster JC |
| Citation(s) |
32936072 |
| |
| Submission date |
Aug 21, 2020 |
| Last update date |
Oct 13, 2020 |
| Contact name |
Julia M Rogers |
| E-mail(s) |
julia_rogers@hms.harvard.edu
|
| Organization name |
Harvard Medical School
|
| Department |
BCMP
|
| Lab |
Blacklow Lab
|
| Street address |
45 Shattuck Street
|
| City |
Boston |
| State/province |
Massachusetts |
| ZIP/Postal code |
02115 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA658531 |
| SRA |
SRP278379 |
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