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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Apr 11, 2009 |
| Title |
Salivary gland during development and onset of xerostomia in murine model of Sjögren's syndrome-like disease |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Differential gene expression in the salivary gland during development and onset of xerostomia in Sjögren’s syndrome-like disease of the C57BL/6.NOD-Aec1Aec2 mouse.
Recently, we reported the development of the C57BL/6.NOD-Aec1Aec2 mouse that carries two genetic intervals derived from the NOD mouse capable of conferring Sjögren’s syndrome (SjS)-like disease in SjS-non-susceptible C57BL/6 mice.
In an attempt to define the molecular bases underlying onset of stomatitis sicca (xerostomia) in this C57BL/6.NOD-Aec1Aec2 mouse model, we have carried out a study utilizing microarray technology.
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| Overall design |
The present study was designed to define the changing gene expression profiles within the salivary glands of C57BL/6.NOD-Aec1Aec2 mice at five time points representing a pre-disease stage (4 weeks), the early pre-clinical stage (8 weeks), the initial influx of leukocytes into the salivary glands (12 weeks), the early clinical phase of autoimmunity (16 weeks), and the early onset of clinical SjSlike disease characterized by secretory dysfunction (20 weeks). The C57BL/6.NOD-Aec1Aec2 mouse is a model of primary SjS in which the Idd3 region of chromosome 3 and the Idd5 region of chromosome 1 derived from the NOD mouse were bred into the non-autoimmune C57BL/6 mouse, resulting in a SjS-like disease susceptibility that mimics both the pathophysiological characteristics and reduced secretory responses observed with NOD mice during development and onset of disease. This SjS-susceptible strain was designated C57BL/6.NOD-Aec1Aec2, where Aec1 corresponds to Idd3 (of chromosome 3) and Aec2 corresponds to Idd5 (of chromosome 1).
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| Contributor(s) |
Nguyen CQ, Sharma A, Lee BH, She J, McIndoe RA, Peck AB |
| Citation(s) |
19379516, 21666236, 35682784, 36233010 |
| Submission date |
Apr 10, 2009 |
| Last update date |
Oct 31, 2022 |
| Contact name |
Ammon B Peck |
| E-mail(s) |
Peck@pathology.ufl.edu
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| Phone |
352-294-4211
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| Organization name |
University of Florida
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| Department |
Department of Infectious Diseases & Pathology
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| Street address |
1945 SW 16th Avenue
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| City |
Gainesville |
| State/province |
FL |
| ZIP/Postal code |
32610 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (25)
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| GSM391443 |
Salivary glands at 4 weeks, biological rep1 |
| GSM391444 |
Salivary glands at 4 weeks, biological rep2 |
| GSM391445 |
Salivary glands at 4 weeks, biological rep3 |
| GSM391446 |
Salivary glands at 4 weeks, biological rep4 |
| GSM391447 |
Salivary glands at 4 weeks, biological rep5 |
| GSM391448 |
Salivary glands at 8 weeks, biological rep1 |
| GSM391449 |
Salivary glands at 8 weeks, biological rep2 |
| GSM391450 |
Salivary glands at 8 weeks, biological rep3 |
| GSM391451 |
Salivary glands at 8 weeks, biological rep4 |
| GSM391452 |
Salivary glands at 8 weeks, biological rep5 |
| GSM391453 |
Salivary glands at 12 weeks, biological rep1 |
| GSM391454 |
Salivary glands at 12 weeks, biological rep2 |
| GSM391455 |
Salivary glands at 12 weeks, biological rep3 |
| GSM391456 |
Salivary glands at 12 weeks, biological rep4 |
| GSM391457 |
Salivary glands at 12 weeks, biological rep5 |
| GSM391458 |
Salivary glands at 16 weeks, biological rep1 |
| GSM391459 |
Salivary glands at 16 weeks, biological rep2 |
| GSM391460 |
Salivary glands at 16 weeks, biological rep3 |
| GSM391461 |
Salivary glands at 16 weeks, biological rep4 |
| GSM391462 |
Salivary glands at 16 weeks, biological rep5 |
| GSM391463 |
Salivary glands at 20 weeks, biological rep1 |
| GSM391464 |
Salivary glands at 20 weeks, biological rep2 |
| GSM391465 |
Salivary glands at 20 weeks, biological rep3 |
| GSM391466 |
Salivary glands at 20 weeks, biological rep4 |
| GSM391467 |
Salivary glands at 20 weeks, biological rep5 |
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| Relations |
| BioProject |
PRJNA115643 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE15640_RAW.tar |
89.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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