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| Status |
Public on Jul 30, 2004 |
| Title |
Vehicle and sAPPalpha-treated hippocampal slice cultures |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Gene expression changes induced by alpha-secretase cleaved amyloid precursor protein (sAPPalpha) in organotypic hippocampal slice cultures of male, postnatal day 15 mice (C57B6/SJL). Hippocampal slice cultures were treated with phosphate buffered saline (GSM26700, GSM26701, GSM26702) or 1 nM sAPPalpha (GSM26703, GSM26704, GSM26705) for 24 h. Each sample consists of total RNA isolated from 8-12 slices from 4 mice. Data were analyzed with MAS 5.0 and scaled to 2500. sAPPalpha induces the amyloid sequestration protein transthyretin, insulin-like growth factor 2, insulin-like growth factor binding protein 2, and other genes involved in protective pathways such as apoptosis inhibition, detoxification, and retinol transport.
Keywords = Alzheimer's disease
Keywords = neuroprotection
Keywords = sAPPalpha
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| Contributor(s) |
Stein TD, Johnson JA |
| Citation(s) |
15342738 |
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| Submission date |
Jul 09, 2004 |
| Last update date |
Feb 18, 2018 |
| Contact name |
Thor D Stein |
| E-mail(s) |
tdstein@wisc.edu
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| Phone |
(608)262-4789
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| Fax |
(608)262-5345
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| Organization name |
University of Wisconsin-Madison
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| Street address |
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| City |
Madison |
| State/province |
WI |
| ZIP/Postal code |
53705-2222 |
| Country |
USA |
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| Platforms (1) |
| GPL81 |
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA89959 |
| Supplementary data files not provided |
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