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Series GSE1555 Query DataSets for GSE1555
Status Public on Jul 30, 2004
Title Vehicle and sAPPalpha-treated hippocampal slice cultures
Organism Mus musculus
Experiment type Expression profiling by array
Summary Gene expression changes induced by alpha-secretase cleaved amyloid precursor protein (sAPPalpha) in organotypic hippocampal slice cultures of male, postnatal day 15 mice (C57B6/SJL). Hippocampal slice cultures were treated with phosphate buffered saline (GSM26700, GSM26701, GSM26702) or 1 nM sAPPalpha (GSM26703, GSM26704, GSM26705) for 24 h. Each sample consists of total RNA isolated from 8-12 slices from 4 mice. Data were analyzed with MAS 5.0 and scaled to 2500. sAPPalpha induces the amyloid sequestration protein transthyretin, insulin-like growth factor 2, insulin-like growth factor binding protein 2, and other genes involved in protective pathways such as apoptosis inhibition, detoxification, and retinol transport.
Keywords = Alzheimer's disease
Keywords = neuroprotection
Keywords = sAPPalpha
Contributor(s) Stein TD, Johnson JA
Citation(s) 15342738
Submission date Jul 09, 2004
Last update date Feb 18, 2018
Contact name Thor D Stein
Phone (608)262-4789
Fax (608)262-5345
Organization name University of Wisconsin-Madison
Street address
City Madison
State/province WI
ZIP/Postal code 53705-2222
Country USA
Platforms (1)
GPL81 [MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array
Samples (6)
GSM26700 vehicle #1
GSM26701 vehicle #2
GSM26702 vehicle #3
BioProject PRJNA89959

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