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Series GSE154964 Query DataSets for GSE154964
Status Public on Dec 02, 2020
Title Transcriptome map of cancerous and para-cancerous tissues in patients with liver hepatocellular carcinoma
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary To validate CXCL12 and IL7R expression between cancerous and paracancerous, five cancer and five paracancerous tissues,wihch were obtained from five LIHC patients undergoing liver cancer surgery at the Guangdong Second Provincial General Hospital,were performed RNA-seq. The RNA-seq data showed a significant difference in CXCL12 expression between cancerous and paracancerous tissues (p =0.04), as well as the IL7R expression (p<0.01). There was also a significant difference between cancerous and paracancerous samples in NK cells (resting) (p = 0.0014), M1 macrophages (p = 0.0058), CD8+ T cells (p = 0.0026), and Tregs (p = 0.0015) in the immunocyte infiltration analysis.
 
Overall design Examination of differences in transcriptome expression levels between cancerous and para-cancerous tissues of liver hepatocellular carcinoma patients
 
Contributor(s) He K, Liu S, Xiang G, Zhan M
Citation(s) 33344233
Submission date Jul 23, 2020
Last update date Dec 22, 2020
Contact name Ke He
Organization name Guangdong Second Provincial General Hospital
Street address 466 Xingangdong Road, Guangzhou
City Guangzhou
State/province Guangdong
ZIP/Postal code 510317
Country China
 
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (10)
GSM4685031 S001: Para-cancerous - 001_HCC
GSM4685032 S002: Para-cancerous - 002_HCC
GSM4685033 S003: Para-cancerous - 003_HCC
Relations
BioProject PRJNA648076
SRA SRP273256

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE154964_HCC_gene_expression.txt.gz 598.0 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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