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| Status |
Public on Jan 24, 2021 |
| Title |
High throughput sequncing for YTHDC1 binding RNAs [ChIRP-seq] |
| Organism |
Mus musculus |
| Experiment type |
Other
|
| Summary |
N6-methyladenoisne (m6A) plays critical roles in many biological processes. However, the function of m6A at the early phase of mammalian development remains poorly understood. Here we show that m6A reader Ythdc1 is required for the proliferation of mouse embryonic stem cells (mESCs) in an m6A-dependent manner and its deletion resets mESCs back to a 2C-like state.
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| Overall design |
We analyzed the transcriptome expression and epigenetic profiles after YTHDC1 Knock out treated only with DMSO in mouse embyronic stem cells.
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| Contributor(s) |
He J |
| Citation(s) |
33658714 |
| |
| Submission date |
Jul 13, 2020 |
| Last update date |
Apr 25, 2021 |
| Contact name |
Jiangping He |
| E-mail(s) |
he_jiangping@grmh-gdl.cn
|
| Organization name |
Guangzhou Institutes of Biomedicine and Health (GIBH), CAS
|
| Street address |
Kai yuan avenue 190
|
| City |
GuangZhou |
| ZIP/Postal code |
510530 |
| Country |
China |
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| Platforms (1) |
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| Samples (36)
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| This SubSeries is part of SuperSeries: |
| GSE146467 |
The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity |
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| Relations |
| BioProject |
PRJNA645914 |
| SRA |
SRP271631 |
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