|
| Status |
Public on Jun 10, 2021 |
| Title |
The clinical significance of regulatory variants at the GDF5 locus in joint disease |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Genetic variants in cis-regulatory regions of GDF5 can lead to common joint diseases with high degrees of joint specificity.
|
| |
|
| Overall design |
Examination of open chromatin regions in multiple different growth plates (proximal vs distal femur, tibia) and acetabulum at E67
|
| |
|
| Contributor(s) |
Capellini TD, Richard D, Young M, Muthuirulan P |
| Citation(s) |
34230488 |
| |
| Submission date |
Jun 25, 2020 |
| Last update date |
Jul 16, 2021 |
| Contact name |
Terence D Capellini |
| E-mail(s) |
drichard@g.harvard.edu, tcapellini@g.harvard.edu
|
| Phone |
6173010673
|
| Organization name |
Harvard Univserity
|
| Department |
Human Evolutionary Biology
|
| Lab |
Capellini
|
| Street address |
11 Divinity Avenue
|
| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02138 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (5)
|
|
| Relations |
| BioProject |
PRJNA641883 |
| SRA |
SRP268820 |
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