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| Status |
Public on Jun 16, 2023 |
| Title |
Molecular analysis in SADBE-induced ACD (Allergic contact dermatitis) model |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The mechanisms underlying pruritus of SADBE induced ACD (Allergic contact dermatitis) remain poorly understood,due to limited clinical data and animal studies. In this study, we investigated whether there are certain key signaling molecules downstream of the recently identified peptides mediating itch in the spinal cord. We investigated the changes in the trascriptome by performing RNAseq of cervical spinal cords in control and SADBE induced ACD model. Our study represents the detailed analysis of transcriptomes of spinal cord in chronic itch model with biologic replicates, generated by RNA-seq technology.
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| Overall design |
six mice (3 controls and 3 ACD) were sacrificed. Cervical spinal cord isolation is followed by RNA extraction of single samples, library preparation and sequencing.
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| Contributor(s) |
Liu X, Wang Y, Wang D, Wen Y, Tao A |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jun 17, 2020 |
| Last update date |
Jun 18, 2023 |
| Contact name |
Xueting Liu |
| E-mail(s) |
xuetingliu2019@126.com
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| Organization name |
The Second Affiliated Hospital of Guangzhou Medical University
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| Lab |
Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology
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| Street address |
Changgangdong 250
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| City |
Guangzhou |
| ZIP/Postal code |
510260 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA639957 |
| SRA |
SRP267622 |
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