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Series GSE15222 Query DataSets for GSE15222
Status Public on Apr 10, 2009
Title Genetic control of human brain transcript expression in Alzheimer’s disease.
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We recently surveyed the relationship between the human brain transcriptome and genome in a series of neuropathologically normal postmortem samples. We now have analyzed additional samples with a confirmed pathologic diagnosis of late onset Alzheimer's disease (LOAD, final n=187 controls, 176 cases). Nine percent of the cortical transcripts we analyzed had expression profiles correlated with their genotypes in the combined cohort and approximately 5% of transcripts had SNP-transcript relationships that could distinguish LOAD samples. Two of these transcripts have been previously implicated in LOAD candidate gene SNP-expression screens. This study shows how the relationship between common inherited genetic variants and brain transcript expression can be used in the study of human brain disorders. We suggest that studying the transcriptome as a quantitative endo-phenotype has greater power to find risk SNPs influencing expression than the use of discrete diagnostic categories such as presence or absence of disease. see DOI:10.1016/j.ajhg.2009.03.011 for further details and complete author list.
Overall design Expression quantitative trait loci study using human brain from 363 cortical samples. Affymetrix 500K chip for genotyping, Illumina ref-seq 8 chip for expression. Genotyping data will be available at dbGAP.
Contributor(s) Webster J, Gibbs R, Myers A
Citation(s) 19361613
Submission date Mar 13, 2009
Last update date Mar 21, 2012
Contact name Amanda Myers
Organization name Miller School of Medicine, University of Miami
Department Psychiatry and Behavioral Sciences
Street address 1600 NW 10th Ave
City Miami
State/province FL
ZIP/Postal code 33136
Country USA
Platforms (1)
GPL2700 Sentrix HumanRef-8 Expression BeadChip
Samples (363)
GSM225652 WGACON-1
GSM225662 WGACON-6
GSM225664 WGACON-7
BioProject PRJNA116473

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary data files not provided
Processed data included within Sample table

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