|
Status |
Public on Dec 09, 2020 |
Title |
Patient-Derived Orthotopic Xenografts and Cell Lines from Pediatric High-Grade Glioma Recapitulate Heterogeneity of Histopathology, Molecular Signatures and Drug Response |
Organism |
Homo sapiens |
Experiment type |
Methylation profiling by genome tiling array
|
Summary |
We established 21 patient-derived pHGG orthotopic xenograft (PDOX) models and 8 matched cell lines from diverse pHGG subgroups. Models recapitulated histopathology, DNA methylation signatures, mutations and gene expression patterns of the patient tumors from which they were derived, and included rare subgroups not well-represented by existing models. We also included 6 DIPG cell lines generously shared by Dr. Michelle Monje (Stanford University). An online interactive data portal is available to explore associated detailed molecular characterization and HTS chemical sensitivity data.
|
|
|
Overall design |
Bisulphite converted DNA from these samples were hybridised to the Illumina Infinium MethylationEPIC or HumanMethylation450 BeadChip
|
|
|
Contributor(s) |
Gudenas B, Xu K, Baker SJ |
Citation(s) |
34215733 |
Submission date |
Jun 08, 2020 |
Last update date |
Jul 27, 2021 |
Contact name |
Suzanne J. Baker |
E-mail(s) |
Suzanne.Baker@STJUDE.ORG
|
Organization name |
ST. JUDE CHILDREN'S RESEARCH HOSPITAL
|
Street address |
262 Danny Thomas Place
|
City |
MEMPHIS |
State/province |
TENNESSEE |
ZIP/Postal code |
38105 |
Country |
USA |
|
|
Platforms (2) |
GPL13534 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482) |
GPL21145 |
Infinium MethylationEPIC |
|
Samples (55)
|
|
Relations |
BioProject |
PRJNA638139 |