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Series GSE150468 Query DataSets for GSE150468
Status Public on May 21, 2020
Title Genome-wide DNA methylation analysis in cfDNA from pancreatic cancer patients
Organism Homo sapiens
Experiment type Methylation profiling by high throughput sequencing
Summary Heterogeneity in DNA methylation status may exist between primary tumors and cfDNA. We compared the genome-wide DNA methylation status between FNA sample of pancreatic tumor and cfDNA samples from the same patients. MBD-sequencing (seq) was performed in paired samples of FNA and cfDNA from two patients.
The majority of DNA methylation peaks overlapped in FNA and cfDNA samples (82.6% and 82.9% in patients #1 and #73, respectively). DNA methylation levels of each gene in FNA and cfDNA samples were highly correlated with each other (r=0.98 and 0.97 in samples 1 and 73, respectively)
Overall design DNA methylation status was analyzed by MBD-seq in cfDNA from pancreatic cancer patients and corresponding tumor and cfDNA from normal patients.
Contributor(s) Kondo Y, Shinjo K
Citation(s) 32520974
Submission date May 13, 2020
Last update date Aug 20, 2020
Contact name Keiko Shinjo
Phone 0527442463
Organization name Nagoya Univ. Graduate School of Medicine
Department Cancer Biology
Street address 65 Tsurumai, Showa-ku
City Nagoya
State/province Aichi
ZIP/Postal code 466-8550
Country Japan
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (6)
GSM4550978 cfDNA1
GSM4550979 cfDNA73
GSM4550980 FNA1
BioProject PRJNA632511
SRA SRP261413

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Supplementary file Size Download File type/resource
GSE150468_RAW.tar 60.4 Mb (http)(custom) TAR (of TXT)
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Raw data are available in SRA
Processed data provided as supplementary file

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