|
| Status |
Public on Dec 08, 2020 |
| Title |
Che-1/AATF-induced transcriptionally active chromatin promotes cell proliferation in Multiple Myeloma |
| Organisms |
Homo sapiens; Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We have strong evidence on the essential role of Che-1 protein in promoting the proliferation of MM cells by sustaining chromatin dynamics and cellular transcription on a global scale using numerous experimental approaches, including a generation of a specific transgenic mouse model.
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| |
|
| Overall design |
Examination of RNA-seq, BRD4, H3K27ac, ATAC-seq, HDAC in KMS27 cell lines before and upon Che interference. ATAC-seq and RNA-seq data of wild and vk-Che mice (overexpression).
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| |
|
| Contributor(s) |
Bruno T, De Nicola F, Goeman F, Pallocca M, Corleone G |
| Citation(s) |
33186461, 38368441 |
| |
| Submission date |
Apr 21, 2020 |
| Last update date |
Apr 10, 2024 |
| Contact name |
Maurizio Fanciulli |
| E-mail(s) |
maurizio.fanciulli@ifo.gov.it
|
| Organization name |
IRCCS National Institute of Cancer Regina Elena
|
| Street address |
via Chianesi
|
| City |
Rome |
| ZIP/Postal code |
00144 |
| Country |
Italy |
| |
|
| Platforms (2) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (33)
|
|
| Relations |
| BioProject |
PRJNA627186 |
| SRA |
SRP257744 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE149031_RAW.tar |
4.4 Gb |
(http)(custom) |
TAR (of BED, BROADPEAK, BW) |
| GSE149031_RNA_KMS27_cuffdiff_diff_analysis.txt.gz |
1.1 Mb |
(ftp)(http) |
TXT |
| GSE149031_RNA_KMS27_deseq_diff_analysis.txt.gz |
710.3 Kb |
(ftp)(http) |
TXT |
| GSE149031_RNA_KMS27_spikein_count.txt.gz |
1.2 Kb |
(ftp)(http) |
TXT |
| GSE149031_RNA_mm9_deseq2.xlsx |
1.6 Mb |
(ftp)(http) |
XLSX |
| GSE149031_RNA_mm9_spikein_counts.tsv.gz |
1.3 Kb |
(ftp)(http) |
TSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
| Processed data provided as supplementary file |
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