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| Status |
Public on Apr 20, 2021 |
| Title |
ATAC sequencing of esophageal cells from wild type and Krt5SmoM2 mice |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
In this study, we used ATAC sequencing to compare the chromatin landscape of esophageal cells in which hedgehog (HH) pathway has been activated (K5SmoM2), to control esophageal cells (WT). We identified more than 50% of the peaks differentially opened in both conditions. Among these differentially opened peaks in EpHI cells, we identified chromatin regions in key columnar markers. Taken together these results show that HH pathway activation triggers chromatin landscape remodeling to facilitate transcommitment.
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| |
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| Overall design |
Examination of chromatin modifications in esophageal cells from wild type (WT) and Krt5SmoM2 mice by deep sequencing using Illumina
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| |
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| Contributor(s) |
Beck B, Vercauteren Drubbel A |
| Citation(s) |
33882290 |
| |
| Submission date |
Apr 17, 2020 |
| Last update date |
Jul 20, 2021 |
| Contact name |
Alizee Vercauteren Drubbel |
| E-mail(s) |
alizeevd@gmail.com
|
| Organization name |
Université Libre de Bruxelles
|
| Lab |
Beck lab
|
| Street address |
808 route de Lennik
|
| City |
Anderlecht |
| ZIP/Postal code |
1070 |
| Country |
Belgium |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (11)
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| This SubSeries is part of SuperSeries: |
| GSE148876 |
RNA-seq and ATAC-sequencing of esophageal cells after HH pathway activation |
|
| Relations |
| BioProject |
PRJNA626007 |
| SRA |
SRP256977 |
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