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Series GSE148549 Query DataSets for GSE148549
Status Public on Apr 10, 2024
Title Functionally distinct subset of monocytes in mouse and human blood [ATAC-Seq]
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Here, we used an inducible and reversible system to pause myeloid differentiation at a self-renewing state. These cells were clonally isolated and allowed to differentiate to test whether function was clone-specific and clonally restricted. We found that monocytic subsets exist with inherent, restricted capabilities which differ in their capacity to perform traditional monocytic functions.
 
Overall design We performed high-throughput ATAC-sequencing on both progenitors and monocyte ER-Hoxb8 clones, clonally paired as progenitors and mature cells.
 
Contributor(s) Scadden DT
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Submission date Apr 13, 2020
Last update date Apr 10, 2024
Contact name David T Scadden
E-mail(s) dscadden@mgh.harvard.edu
Organization name MGH
Department Center for Regenerative Medicine
Street address 185 Cambridge St
City Boston
State/province MA
ZIP/Postal code 02114
Country USA
 
Platforms (2)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (48)
GSM4473392 Clone1_Plus [ATAC-seq]
GSM4473393 Clone2_Plus [ATAC-seq]
GSM4473394 Clone3_Plus [ATAC-seq]
This SubSeries is part of SuperSeries:
GSE148555 Functionally distinct subset of monocytes in mouse and human blood
Relations
BioProject PRJNA625020
SRA SRP256264

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE148549_RAW.tar 63.2 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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