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Status |
Public on Apr 10, 2024 |
Title |
Functionally distinct subset of monocytes in mouse and human blood [ATAC-Seq] |
Organism |
Mus musculus |
Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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Summary |
Here, we used an inducible and reversible system to pause myeloid differentiation at a self-renewing state. These cells were clonally isolated and allowed to differentiate to test whether function was clone-specific and clonally restricted. We found that monocytic subsets exist with inherent, restricted capabilities which differ in their capacity to perform traditional monocytic functions.
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Overall design |
We performed high-throughput ATAC-sequencing on both progenitors and monocyte ER-Hoxb8 clones, clonally paired as progenitors and mature cells.
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Contributor(s) |
Scadden DT |
Citation missing |
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Submission date |
Apr 13, 2020 |
Last update date |
Apr 10, 2024 |
Contact name |
David T Scadden |
E-mail(s) |
dscadden@mgh.harvard.edu
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Organization name |
MGH
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Department |
Center for Regenerative Medicine
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Street address |
185 Cambridge St
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City |
Boston |
State/province |
MA |
ZIP/Postal code |
02114 |
Country |
USA |
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Platforms (2) |
GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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Samples (48)
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This SubSeries is part of SuperSeries: |
GSE148555 |
Functionally distinct subset of monocytes in mouse and human blood |
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Relations |
BioProject |
PRJNA625020 |
SRA |
SRP256264 |