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| Status |
Public on Aug 28, 2020 |
| Title |
Coordination of Rel Expression by MAP3K4, CBP, and HDAC6 Controls TS cell Phenotype (RNA-seq) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Trophoblast stem cells lack MAP3K4 activity (TSKI4 cells) switch from epithelial phenotype to intermediate phenotype. Loss of epithelial phenotype is due to the loss of CBP histone acetyltransferase activity and the gain of histone deacetylase HDAC6 expression and activity. In our work, we identify a small network of 183 genes whose expression is co-regulated by MAP3K4, CBP, and HDAC6. Further, we define the key role of one of these co-regulated genes, Rel, in inducing epithelial phenotype in intermediate TSKI4 cells.
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| Overall design |
RNA-seq samples from TSWT, TSWTCBsh,TSKI4, TSKI4H6sh
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| Contributor(s) |
Shendy NA, Raghu D, Roy S, Perry CH, Safi A, Branco MR, Homayouni R, Abell AN |
| Citation(s) |
32859943 |
| Submission date |
Apr 10, 2020 |
| Last update date |
Sep 08, 2020 |
| Contact name |
Amy Abell |
| E-mail(s) |
anabell@memphis.edu
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| Organization name |
The University of Memphis
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| Department |
Biological Sciences
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| Lab |
Abell
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| Street address |
3774 Walker Ave
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| City |
Memphis |
| State/province |
TN |
| ZIP/Postal code |
38152 |
| Country |
USA |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA624653 |
| SRA |
SRP256220 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE148496_RAW.tar |
7.8 Mb |
(http)(custom) |
TAR (of XLSX) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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