GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE148496 Query DataSets for GSE148496
Status Public on Aug 28, 2020
Title Coordination of Rel Expression by MAP3K4, CBP, and HDAC6 Controls TS cell Phenotype (RNA-seq)
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Trophoblast stem cells lack MAP3K4 activity (TSKI4 cells) switch from epithelial phenotype to intermediate phenotype. Loss of epithelial phenotype is due to the loss of CBP histone acetyltransferase activity and the gain of histone deacetylase HDAC6 expression and activity. In our work, we identify a small network of 183 genes whose expression is co-regulated by MAP3K4, CBP, and HDAC6. Further, we define the key role of one of these co-regulated genes, Rel, in inducing epithelial phenotype in intermediate TSKI4 cells.
Overall design RNA-seq samples from TSWT, TSWTCBsh,TSKI4, TSKI4H6sh
Contributor(s) Shendy NA, Raghu D, Roy S, Perry CH, Safi A, Branco MR, Homayouni R, Abell AN
Citation(s) 32859943
Submission date Apr 10, 2020
Last update date Sep 08, 2020
Contact name Amy Abell
Organization name The University of Memphis
Department Biological Sciences
Lab Abell
Street address 3774 Walker Ave
City Memphis
State/province TN
ZIP/Postal code 38152
Country USA
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (4)
GSM4472496 TSWT
GSM4472497 TSWTCBPsh
GSM4472498 TSKI4
BioProject PRJNA624653
SRA SRP256220

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE148496_RAW.tar 7.8 Mb (http)(custom) TAR (of XLSX)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap