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Series GSE148282 Query DataSets for GSE148282
Status Public on Apr 09, 2020
Title role of exosomal miRNAs in anthracycline-induced liver injury in breast cancer patients
Organism Homo sapiens
Experiment type Non-coding RNA profiling by high throughput sequencing
Summary Anthracycline-induced liver injury (AILI) is one of the serious complications of anthracycline-based adjuvant chemotherapy for postoperative breast cancer patients. Exosomal miRNAs, as signaling molecules in intercellular communication, play the essential roles in the drug-induced liver injury (DILI). However, the expression profiles of them in patients with AILI remains unknown. Seven post-chemotherapy patients were recruited in this study. After isolated plasma-derived exosomes, small RNA sequencing revealed exosomal miRNA profiles and differentially expressed miRNAs (DE-miRNAs) were identified between the liver injury group and non-liver injury group.
Overall design Plasma exosomal miRNA profiles of breast cancer patients were generated by deep sequencing using Illumina Hiseq 2500 platform.
Contributor(s) Zhang Y, Wang D, Shen D, Luo Y, Che YQ
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Submission date Apr 08, 2020
Last update date Apr 11, 2020
Contact name yue zhang
Organization name Chinese Academy of Medical Sciences and Peking Union Medical College
Street address No.17 Panjiayuan Nanli, Chaoyang District
City Beijing
ZIP/Postal code 100021
Country China
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (7)
GSM4459550 A12-04
GSM4459551 A12-08
GSM4459552 A12-01
BioProject PRJNA623726
SRA SRP255698

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE148282_RAW.tar 80.0 Kb (http)(custom) TAR (of TXT)
GSE148282_Supplementary_novel.miRNA.sequence.xlsx 24.5 Kb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data provided as supplementary file

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