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Status |
Public on Apr 22, 2020 |
Title |
Single-cell landscape of bronchoalveolar immune cells in COVID-19 patients |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing Other
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Summary |
Immune characteristics associated with Coronavirus Disease-2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid (BALF) immune cells from patients with varying severity of COVID-19 disease and from healthy subjects using single-cell RNA-sequencing. Proinflammatory monocyte-derived macrophages were abundant in the BALF from severe COVID-9 patients. Moderate cases were characterized by the presence of highly clonally expanded tissue-resident CD8+ T cells. This atlas of the bronchoalveolar immune-microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.
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Overall design |
Using 10x genomics to measure single-cell RNA sequence (scRNA-seq)/TCR-seq to comprehensively characterize the lung immune microenvironment in the bronchoalveolar lavage fluid (BALF) from 6 severe and 3 moderate COVID-19 patients and 3 healthy control.
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Contributor(s) |
Liao M, Liu Y, Yuan J, Wen Y, Xu G, Zhao J, Cheng L, Li J, Wang X, Wang F, Liu L, Amit I, Zhang S, Zhang Z |
Citation(s) |
32398875, 39369126 |
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medRxiv: https://doi.org/10.1101/2020.02.23.20026690
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Submission date |
Feb 25, 2020 |
Last update date |
Nov 05, 2024 |
Contact name |
Zheng Zhang |
Organization name |
Shenzhen 3rd People's Hospital
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Street address |
No. 29, Bulan Road
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City |
Shenzhen |
State/province |
Guangdong |
ZIP/Postal code |
454171 |
Country |
China |
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Platforms (1) |
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Samples (21)
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Relations |
BioProject |
PRJNA608742 |
SRA |
SRP250732 |
Supplementary file |
Size |
Download |
File type/resource |
GSE145926_RAW.tar |
225.1 Mb |
(http)(custom) |
TAR (of CSV, H5) |
SRA Run Selector |
Raw data are available in SRA |
Processed data provided as supplementary file |
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