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| Status |
Public on Feb 04, 2009 |
| Title |
Gene Expression Profiling of Tumor Microenvironment during Breast Cancer Progression |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
To better understand the role of tumor microenvironment in breast cancer progression, we combined laser capture microdissection and microarray analysis to provide a comprehensive catalog of gene expression changes in both tumor and tumor-associated stroma.
Keywords: cancer vs. normal
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| |
|
| Overall design |
We used LCM to isolate the epithelial and stroma compartments separately from each of 14 fresh frozen primary breast cancer biopsies. In the epithelial compartment, we captured normal (N) and malignant (DCIS or IDC or both where available) epithelium from each tissue slide. In the stroma compartment, we captured both normal stroma away from the malignant lesion (NSS) and the DCIS-associated stroma (ISS) and/or IDC-associated stroma (INVS) whenever possible.
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| |
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| Contributor(s) |
Ma X, Sgroi DC |
| Citation(s) |
19187537 |
| Submission date |
Jan 23, 2009 |
| Last update date |
Mar 20, 2012 |
| Contact name |
Xiao-Jun Ma |
| E-mail(s) |
xiao-jun.ma@biotheranostics.com
|
| Organization name |
bioTheranostics, Inc.
|
| Street address |
11025 Roselle St, Suite 200
|
| City |
San Diego |
| State/province |
CA |
| ZIP/Postal code |
CA, 92121 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL1352 |
[U133_X3P] Affymetrix Human X3P Array |
|
| Samples (66)
|
|
| Relations |
| BioProject |
PRJNA111643 |
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