GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE143743 Query DataSets for GSE143743
Status Public on Jan 17, 2020
Title Knocking out C9ORF72 exacerbates axonal trafficking defects associated with hexanucleotide repeat expansion and reduces levels of heat shock proteins I
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary iPSCs with mutant C9ORF72 were edited using CRISPR/Cas9 (1) to knockout C9ORF72 or, alternatively, (2) to correct the ALS mutation, followed by differentiation into motor neurons.
Overall design We tested the effects of mutations in C9ORF72 on iPSC-derived MNs by comparing to isogenic gene-corrected controls. In addition, we generated a knockout in MNs containing mutant C9ORF72 to test if this would exacerbate MN degeneration.
Contributor(s) Sterneckert J, Abo-Rady M
Citation(s) 32084385
Submission date Jan 15, 2020
Last update date Apr 21, 2020
Contact name Jared Sterneckert
Organization name TU Dresden
Department Center for Molecular and Cellular Bioengineering (CMCB)
Lab iPS Cells and Neurodegenerative Disease
Street address Fetscherstra├če 105
City Dresden
State/province Saxony
ZIP/Postal code 01307
Country Germany
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (9)
GSM4273603 C9-1_1
GSM4273604 C9-1_2
GSM4273605 C9-1_3
BioProject PRJNA601468
SRA SRP242090

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE143743_bfx1299.genecounts.csv.gz 4.8 Mb (ftp)(http) CSV
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap