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| Status |
Public on Jan 14, 2020 |
| Title |
Extensive DNA methylation variation across a single ADPKD kidney |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by high throughput sequencing
|
| Summary |
We have previously described global hypomethylation and site-specific DNA methylation changes which are associated with disease-state renal tissue in Autosomal Dominant Polycystic Kidney Disease (ADPKD). However, to-date there are no available data on the pattern of DNA methylation across an ADPKD kidney. Here we describe the methylome of eight individual cysts from a single ADPKD patient and peform an intra-individual analysis to identify regions of DNA methylation variability.
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| Overall design |
Here we generated single-nucleotide resolution methylomes of eight individual ADPKD cysts from a single patient using Reduced Representation Bisulfite Sequencing (RRBS).
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| Contributor(s) |
Chatterjee A, Bowden S, Stockwell P, Rodger E, Eccles M, Stayner C |
| Citation(s) |
32351541 |
| Submission date |
Dec 27, 2019 |
| Last update date |
May 07, 2020 |
| Contact name |
Aniruddha Chatterjee |
| E-mail(s) |
aniruddha.chatterjee@otago.ac.nz
|
| Phone |
+64-210701558
|
| Organization name |
University of Otago
|
| Department |
Pathology
|
| Lab |
Epigenetics and Disease
|
| Street address |
270 Great king Street
|
| City |
Dunedin |
| State/province |
Otago |
| ZIP/Postal code |
9054 |
| Country |
New Zealand |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA597894 |
| SRA |
SRP238909 |
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