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Series GSE140810 Query DataSets for GSE140810
Status Public on Apr 15, 2020
Title RNA-seq analysis of transcriptomic changes in macrophage-lineage cells after acute neural injury in larval zebrafish
Organism Danio rerio
Experiment type Expression profiling by high throughput sequencing
Summary Both brain-resident microglia and peripheral macrophages are important cellular effectors of the inflammatory response to neural injury. They respond to neural injury by secreting a wide range of effector molecules including cytokines, chemokines and neurotrophic factors. To identify additional secreted signalling molecules, we used RNA-seq gene expression profiling to detect changes in the transcriptome of macrophage-lineage cells after acute neural injury in larval zebrafish. GO term analysis was then used to analyse the list of differentially expressed genes and identify secreted signalling molecules among them.
Overall design The transcriptomes of FACS-purified macrophage-lineage cells from mpeg1:GFP transgenic zebrafish larvae with or without neural injury were compared.
Contributor(s) Herzog C, Larraz J, Herrgen L
Citation(s) 32366533
Submission date Nov 21, 2019
Last update date May 19, 2020
Contact name Leah Herrgen
Organization name University of Edinburgh
Department Centre for Discovery Brain Sciences
Street address 49 Little France Crescent
City Edinburgh
ZIP/Postal code EH16 4SB
Country United Kingdom
Platforms (1)
GPL24995 Illumina NovaSeq 6000 (Danio rerio)
Samples (12)
GSM4186870 Sham_1
GSM4186871 Sham_2
GSM4186872 Sham_3
BioProject PRJNA591000
SRA SRP231168

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE140810_extended_summary_gene.csv.gz 1.8 Mb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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