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| Status |
Public on Oct 13, 2020 |
| Title |
Gut microbiota regulates tumor via circRNA/miRNA networks I |
| Platform organisms |
Homo sapiens; Mus musculus; Rattus norvegicus |
| Sample organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
Increasing evidence indicates that gut microbiota plays an important role in cancer progression. We have employed RNA-seq or microarray for genome including mRNA, microRNA or circRNA profiling in an gut microbiota -dependent manner, as a discovery platform to identify target genes with the potential to involve in tumor regulation. The deep sequencing analysis reveals regulatory functions of microbiota-mediated circular RNA (circRNA)/microRNA networks that may contribute to cancer progression.
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| Overall design |
Gut microbiota regulated mRNAs expression in tumor were measured in tumor samples of xenograft cancer model including germ-free mice with or without fecal microbiota transplantation (FMT) from specific pathogen free (SPF) mice or Probiotics (such as Bifidobacterium). Gut microbiota regulated no-coding RNAs (including circRNA and microRNA) expression in mice blood samples were measured in specific pathogen free (SPF) mice with or without broad-spectrum antibiotics (ABX) treatment, with or without fecal microbiota transplantation (FMT) from specific pathogen free (SPF) mice or Probiotics (such as Bifidobacterium, EcN) into germ-free mice.
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| Contributor(s) |
Zhang Z, Zhu Z |
| Citation(s) |
32686598 |
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| Submission date |
Nov 13, 2019 |
| Last update date |
Oct 13, 2020 |
| Contact name |
X XX |
| Organization name |
university
|
| Street address |
Road 89
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| City |
X |
| ZIP/Postal code |
11 |
| Country |
China |
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| Platforms (1) |
| GPL18058 |
Exiqon miRCURY LNA microRNA array, 7th generation [miRBase v18, condensed Probe_ID version] |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE140887 |
Gut microbiota regulates tumor via circRNA/miRNA networks |
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| Relations |
| BioProject |
PRJNA589308 |
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