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Status |
Public on Oct 29, 2019 |
Title |
CD47 blockade augmentation of Trastuzumab antitumor efficacy dependent upon antibody-dependent-cellular-phagocytosis |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
|
Summary |
Analysis of HER2 breast tumor immune infiltrates in mice treated with murine Trastuzumab and CD47 checkpoint blockade therapy
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Overall design |
Single Cell RNA Seq (scRNAseq) was performed on endogenous HER2-driven breast cancer in transgenic mice. The goal of this experiment is to compare effects of different antibody therapy combinations on tumor macrophages transcriptome
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Contributor(s) |
Tsao L, Agarwal P, Crosby EJ, Lyerly HK, Hartman ZC |
Citation(s) |
31689243 |
NIH grant(s) |
Grant ID |
Grant title |
Affiliation |
Name |
R01 CA238217 |
Enabling effective anti-tumor immunity from targeted antibodies through dual innate and adaptive immune checkpoint blockade in non-immunogenic cancers |
DUKE UNIVERSITY |
Zachary Conrad Hartman |
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Submission date |
Oct 28, 2019 |
Last update date |
Apr 10, 2020 |
Contact name |
Zachary Conrad Hartman |
E-mail(s) |
zch@duke.edu
|
Phone |
919-684-9197
|
Organization name |
Duke University
|
Department |
Surgery
|
Lab |
Lyerly Lab
|
Street address |
Research Drive MSRB rm 414
|
City |
Durham |
State/province |
NC |
ZIP/Postal code |
27710 |
Country |
USA |
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Platforms (2) |
GPL21273 |
HiSeq X Ten (Mus musculus) |
GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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Samples (13)
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This SubSeries is part of SuperSeries: |
GSE148482 |
Stimulation of oncogene-specific tumor infiltrating T-cells through combined vaccine and alpha-PD1 enable sustained anti-tumor responses against established HER2 breast cancer (BC) |
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Relations |
BioProject |
PRJNA579973 |
SRA |
SRP227233 |