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Series GSE138252 Query DataSets for GSE138252
Status Public on Sep 11, 2020
Title Differential transcriptional responses in human cardiomyocytes
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We report the application of a pericentriolar material 1 (PCM-1) based cardiomyocyte-specific nuclear isolation protocol on human cardiac tissue to specifically ask what transcriptional changes occur in cardiomyocytes of humans with atrial fibrillation. We performed RNA-sequencing on the cardiomyocyte-specific nuclear RNA and found that there are more differentially dysregulated (1343) than similarly regulated transcripts (99) in the right versus left atria. This study is the first of its kind aimed at understanding the transcriptional changes that occur specifically in the left and right atrial cardiomyocytes of humans with atrial fibrillation.
 
Overall design Cardiomyocyte nuclear mRNA profiles of human heart tissue samples (RA, LA, RV, LV).
 
Contributor(s) Rentschler SL
Citation(s) 32841220
Submission date Oct 01, 2019
Last update date Sep 12, 2020
Contact name Tiandao Li
Organization name Washington University
Street address 4444 Forest Park Ave
City St Louis
State/province MO
ZIP/Postal code 63108
Country USA
 
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (48)
GSM4103429 h76ra : Control RA biological replicate 1
GSM4103430 h77la : Control LA biological replicate 1
GSM4103431 h77lv#1 : Control LV biological replicate 1, technical replicate 1
Relations
BioProject PRJNA575223
SRA SRP223876

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE138252_human_2785_merged_gene_name_expression.txt.gz 541.9 Kb (ftp)(http) TXT
GSE138252_human_merged_genebody_exp.txt.gz 1.1 Mb (ftp)(http) TXT
GSE138252_merged_gene_name_expression.txt.gz 1.1 Mb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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