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Series GSE13796 Query DataSets for GSE13796
Status Public on Feb 06, 2009
Title Hierarchical maintenance of MLL myeloid leukemia stem cells
Organism Mus musculus
Experiment type Expression profiling by array
Summary Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells

The genetic programs that promote retention of self-renewing leukemia stem cells (LSCs) at the apex of cellular hierarchies in acute myeloid leukemia (AML) are not known. In a mouse model of human AML, LSCs exhibit variable frequencies that correlate with the initiating MLL oncogene and are maintained in a self-renewing state by a transcriptional sub-program more akin to that of embryonic stem cells (ESCs) than adult stem cells. The transcription/chromatin regulatory factors Myb, Hmgb3 and Cbx5 are critical components of the program and suffice for Hoxa/Meis-independent immortalization of myeloid progenitors when co-expressed, establishing the cooperative and essential role of an ESC-like LSC maintenance program ancillary to the leukemia initiating MLL/Hox/Meis program. Enriched expression of LSC maintenance and ESC-like program genes in normal myeloid progenitors and poor prognosis human malignancies links the frequency of aberrantly self-renewing progenitor-like cancer stem cells to prognosis in human cancer.

This SuperSeries is composed of the SubSeries listed below.
 
Overall design Refer to individual Series.
 
Citation(s) 19200802
Submission date Dec 02, 2008
Last update date Feb 11, 2019
Contact name Tim C Somervaille
E-mail tim.somervaille@cruk.manchester.ac.uk
Organization name Cancer Research UK Manchester Institute
Lab Leukaemia Biology Laboratory
Street address Wilmslow Road
City Manchester
State/province Lancashire
ZIP/Postal code M20 4BX
Country United Kingdom
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (55)
GSM344110 BM_MLL-AF1p_810
GSM344116 BM_MLL-AF1p_801
GSM344124 BM_MLL-AF1p_811
This SuperSeries is composed of the following SubSeries:
GSE13690 Gene expression profiling of murine MLL leukemias (whole BM)
GSE13692 Expression profiling of MLL-AF10 myeloid leukemia cellular subsets
GSE13693 Gene expression profiling of normal mouse myeloid cell populations
Relations
BioProject PRJNA110557

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE13796_RAW.tar 194.1 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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